KROK 1 2009 – Question 37 · KROK (Medicine) · Biological Chemistry
Examination of a 27-year-old patient revealed pathological changes in liver and brain. Blood plasma analysis revealed an abrupt decrease in the copper concentration, urine analysis revealed an increased copper concentration. The patient was diagnosed with Wilson’s degeneration. To confirm the diagnosis it is necessary to study the activity of the following enzyme in blood serum:
- A. Leucine aminopeptidase
- B. Alcohol dehydrogenase
- C. Carbonic anhydrase
- D. Xanthine oxidase
- E. Ceruloplasmin
Hint
Think about the liver defect that traps copper in Wilson disease and which serum protein would therefore be found at a low level.
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