KROK 1 2009 – Question 67 · KROK (Medicine) · Biological Chemistry
Examination of a patient with frequent haemorrhages from the internal organs and mucous membranes revealed proline and lysine within the collagen fibers. Disorder of their hydroxylation is caused by lack of the following vitamin:
- A. Vitamin C
- B. Vitamin E
- C. Vitamin A
- D. Vitamin B1
- E. Vitamin K
Hint
Hydroxylation of proline and lysine in procollagen is an iron-dependent reaction; ask which water-soluble dietary cofactor keeps that iron in its reduced state.
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