KROK 1 2021 – Question 22 · KROK (Medicine) · Biological Chemistry

In von Gierke disease, glycogen accumulation can be observed in liver and kidneys. This disease is caused by deficiency of the following enzyme:

  1. A. Phosphoglucomutase
  2. B. Glucokinase
  3. C. Glycogen phosphorylase
  4. D. Glucose-6-phosphatase
  5. E. Phosphorylase kinase
Hint

In this type I glycogen storage disease the liver cannot release free glucose in the last step of glycogenolysis and gluconeogenesis, causing fasting hypoglycemia.

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