KROK 1 2023 – Question 118 · KROK (Medicine) · Pharmacology
Medical examination detected angina pectoris in a patient. The doctor prescribed the patient metoprolol that reduces the strength and frequency of cardiac contractions and, as a result, reduces the myocardial oxygen demand. What is the mechanism of the therapeutic action of this drug?
- A. Blockade of muscarinic acetylcholine receptors
- B. Blockade of β₂-adrenergic receptors
- C. Stimulation of β₁-adrenergic receptors
- D. Blockade of β₁-adrenergic receptors
- E. Blockade of nicotinic acetylcholine receptors
Hint
Consider which adrenoceptor subtype dominates in the heart and how its antagonism by a cardioselective agent lowers rate, contractility and oxygen consumption.
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