KROK 1 2023 – Question 37 · KROK (Medicine) · Pharmacology
All nonsteroidal anti-inflammatory drugs can damage the gastric mucosa. To find the substances that do not cause this complication, it is necessary to know what it is associated with. To reduce the severity of this complication, the drug's effect on a certain molecular substrate must be reduced. Name this molecular substrate.
- A. Lysosomal enzymes
- B. Kallikrein
- C. Cyclooxygenase-2
- D. Adenylate cyclase
- E. Cyclooxygenase-1
Hint
Consider which prostaglandin-producing enzyme is constitutively active in the stomach, keeping mucus, bicarbonate and mucosal blood flow up, so that a gastric-sparing drug should leave it alone.
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