KROK 1 2017 – Question 81 · KROK (Medicine) · Pathophysiology

A 38-year-old man, who has been suffering from systemic lupus erythematosus for 3 years, developed diffuse renal lesions accompanied by massive edemas, marked proteinuria, hyperlipidemia, and dysproteinemia. What is the most likely mechanism of proteinuria development in this case?

  1. A. Autoimmune damage to the nephrons
  2. B. Increased blood proteins
  3. C. Morbid affection of the urinary tracts
  4. D. Ischemic damage to the tubules
  5. E. Inflammatory damage to the nephrons
Hint

Think about how the underlying systemic disease reaches the kidney and what loss of integrity of the filtration barrier does to the handling of plasma protein.

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