KROK 1 2017 – Question 19 · KROK (Medicine) · Pathophysiology

A 63-year-old man suffers from esophageal carcinoma, presents with metastases into the mediastinal lymph nodes and cancerous cachexia. What pathogenetic stage of neoplastic process is observed in the patient?

  1. A. Promotion
  2. B. Transformation
  3. C. Initiation
  4. D. Progression
  5. E. -
Hint

Order the stages of carcinogenesis from the first genetic hit onward and decide which stage is marked by invasion, metastasis and systemic effects.

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