KROK 1 2017 – Question 14 · KROK (Medicine) · Pathophysiology
A 3-year-old boy with pronounced hemorrhagic syndrome has no antihemophilic globulin A (factor VIII) in the blood plasma. Hemostasis has been impaired at the following stage:
- A. Conversion of prothrombin to thrombin
- B. External mechanism of prothrombinase activation
- C. Internal mechanism of prothrombinase activation
- D. Conversion of fibrinogen to fibrin
- E. Blood clot retraction
Hint
Locate factor VIII in the clotting cascade and decide which early step, upstream of thrombin formation, cannot proceed without it.
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