KROK 1 2016 – Question 112 · KROK (Medicine) · Biological Chemistry
A patient, who has been subsisting exclusively on polished rice, has developed polyneuritis due to thiamine deficiency. What substance is an indicator of such avitaminosis, when it is excreted with urine?
- A. Uric acid
- B. Malate
- C. Methylmalonic acid
- D. Phenyl pyruvate
- E. Pyruvic acid
Hint
Ask which thiamine-dependent enzyme reactions of carbohydrate oxidation stall in deficiency, and what substrate would then build up and spill into urine.
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