KROK 1 2016 – Question 81 · KROK (Medicine) · Pathomorphology

Autopsy of a 40-year-old woman, who died of cerebral hemorrhage during hypertensic crisis, revealed: upper-body obesity, hypertrichosis, hirsutism, stretchmarks on the skin of thighs and abdomen. Pituitary basophil adenoma is detected in the anterior lobe. What diagnosis is the most likely?

  1. A. Simmonds’ disease
  2. B. Essential hypertension
  3. C. Cushing’s disease
  4. D. Hypothalamic obesity
  5. E. Alimentary obesity
Hint

Combine the body-habitus changes, skin striae and hypertension with the pituitary finding to decide which endocrine syndrome and which hormonal axis are involved.

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