KROK 1 2016 – Question 86 · KROK (Medicine) · Pathomorphology
Autopsy of an 8-month-old boy, who died of severe pneumonia complicated with sepsis, revealed absence of thymus. Lymph nodes have no lymphoid follicles and cortical substance. In the spleen the follicles are decreased in size and have no light centers. What is the cause of such changes?
- A. Thymus hypoplasia
- B. Thymus aplasia
- C. Accidental thymic involution
- D. Thymus agenesis
- E. Thymus atrophy
Hint
Think about what an absent thymus, empty T-dependent zones of the lymphoid organs and fatal infection in infancy suggest about when in development the defect arose.
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