KROK 1 2013 – Question 143 · KROK (Medicine) · Biological Chemistry
The genetic defect of pyruvate carboxylase deficiency is the cause of delayed physical and mental development and early death in children. This defect is characterized by lacticemia, lactaciduria, disorder of a number of metabolic pathways. In particular, the following process is inhibited:
- A. Glycolysis and glycogenolysis
- B. Citric acid cycle and gluconeogenesis
- C. Glycogenesis and glycogenolysis
- D. Pentose phosphate pathway and glycolysis
- E. Lipolysis and lipogenesis
Hint
Think about the product of the carboxylation of pyruvate and which pathways depend on that product to proceed.
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