KROK 1 2013 – Question 26 · KROK (Medicine) · Biological Chemistry
A 42-year-old male patient with gout has an increased blood uric acid concentration. In order to reduce the level of uric acid the doctor administered him allopurinol. Allopurinol is the competitive inhibitor of the following enzyme:
- A. Adenosine deaminase
- B. Xanthine oxidase
- C. Adenine phosphoribosyltransferase
- D. Guanine deaminase
- E. Hypoxanthinephosphoribosyltransferase
Hint
Follow purine catabolism to the end product that accumulates in gout and ask which enzyme a substrate analogue would have to block to cut its formation.
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