KROK 1 2011 – Question 88 · KROK (Medicine) · Pharmacology
A 17-year-old girl took a high dose of phenobarbital to commit a suicide. An ambulance doctor cleansed her stomach and gave her an intravenous injection of bemegride and sodium hydrocarbonate solution. What was sodium hydrocarbonate injected for?
- A. For increasing renal excretion of phenobarbital
- B. For bringing the patient to consciousness
- C. For arterial pressure normalization
- D. For phenobarbital inactivation
- E. For breathing stimulation
Hint
Phenobarbital is a weak acid. Think about how a change in urine pH alters the ionisation of such a drug in the kidney tubule and what that does to its passive reabsorption.
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