Question 227 · LEK · Lyme disease

A patient with an enlarging erythema on the arm presented at the doctor’s office. Current diameter of the erythema is about 12 cm. The doctor diagnosed erythema migrans based on the medical history and the appearance of the lesion. Which of the following should be the next step?

  1. A. ELISA assay to detect antibodies against Borrelia in IgM class.
  2. B. ELISA assay to detect antibodies against Borrelia in IgG class.
  3. C. Western-Blot assay to detect antibodies against Borrelia in IgM and IgG classes.
  4. D. blood examination with PCR method to detect the presence of Borrelia antigens.
  5. E. start the treatment with an antibiotic chosen according to recommendations.
Hint

Decide whether a typical skin lesion of early Lyme disease needs any laboratory confirmation before treatment.

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