Question 61 · LEK · Urea cycle

Which of the following rise a suspicion of disturbances of the urea cycle in a neonate:

1) vomiting after the first feeding with proteins in a previously healthy neonate;
2) sudden loss of appetite, tremor, seizures, decreased muscle tone, sleepiness or coma in a previously healthy neonate;
3) agitation and generalized rigidity in a previously healthy neonate;
4) increased concentrations of ammonia in serum;
5) decreased concentrations of ammonia in serum.
The correct answer is:
  1. A. 1,3,4.
  2. B. 1,3,5.
  3. C. 1,2,4.
  4. D. 1,2,5.
  5. E. 3,5.
Hint

Think of the metabolite that accumulates when nitrogen cannot be converted to urea and how it affects the brain after protein feeding begins.

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