Question 149 (part 2) · LEK · Ovarian cancer
Which of the following are true about malignant tumour markers:
1) serum CA 125 levels are always increased in ovarian cancer;
2) the assessment of CA 125 during ovarian cancer chemotherapy should not be proposed;
3) an increased HE 4 protein concentration is observed in malignant tumours of the ovary, lung cancer and pancreatic cancer;
4) endodermal sinus tumour releases alpha-fetoprotein, which is a sensitive marker used to monitor the treatment;
5) an increased CA 125 concentration is observed, for example, in endometriosis, uterine myomas, liver cirrhosis and during menstruation.
The correct answer is:
2) the assessment of CA 125 during ovarian cancer chemotherapy should not be proposed;
3) an increased HE 4 protein concentration is observed in malignant tumours of the ovary, lung cancer and pancreatic cancer;
4) endodermal sinus tumour releases alpha-fetoprotein, which is a sensitive marker used to monitor the treatment;
5) an increased CA 125 concentration is observed, for example, in endometriosis, uterine myomas, liver cirrhosis and during menstruation.
The correct answer is:
- A. 1,2,3,4.
- B. 1,3,4,5.
- C. 2,3,4,5.
- D. 3,4,5.
- E. 1,2.
Hint
Consider how sensitive and specific CA 125 is, its role during treatment, and which marker belongs to which ovarian tumour.
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