Question 108 · LEK · Endometrial cancer
Endometrial cancer is currently the most common female genital cancer in developed countries. The following are the characteristics of its two subtypes:
1) estrogen dependence (positive E + and P + receptor state);
2) aggressive course, frequent metastases;
3) the most common are mutations PTEN, K-ras, microsatellite instability;
4) the most common histopathological type is endometrioid endometrial cancer;
5) the most common mutations are p-53, HER2-neu, p16. The correct combination of characteristics of the first subtype of endometrial cancer is:
2) aggressive course, frequent metastases;
3) the most common are mutations PTEN, K-ras, microsatellite instability;
4) the most common histopathological type is endometrioid endometrial cancer;
5) the most common mutations are p-53, HER2-neu, p16. The correct combination of characteristics of the first subtype of endometrial cancer is:
- A. 1,2,5.
- B. 2,4,5.
- C. 3,4.
- D. 1,3,4.
- E. only 1.
Hint
Type I is the estrogen-related, hyperplasia-associated tumour with a good prognosis; sort each feature by that profile.
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