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Question 34 · LEK · Anti-glomerular basement membrane disease

Indicate the true statements concerning rapidly progressive glomerulonephritis mediated by anti-glomerular basement membrane antibodies (anti-GBM):

1) peak of morbidity occurs in elderly patients of age 60 or more;
2) autoantibodies against the alpha-3 chain of type IV collagen are found in patients’ serum;
3) induction treatment includes pulses of glucocorticosteroids and cyclophosphamide;
4) clinical course is characterized by frequent relapses;
5) renal lesions may be accompanied by pulmonary complications in the form of alveolar hemorrhage.
The correct answer is:
  1. A. 2,3,4.
  2. B. 1,3,4.
  3. C. 1,2,4.
  4. D. 2,3,5.
  5. E. 3,4,5.
Hint

Recall the target antigen, the components of induction therapy and the typical lung involvement in Goodpasture disease.

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