Question 41 · LEK · Gastric acid-reducing drugs
Indicate the false statement concerning proton-pump inhibitors (PPIs):
- A. all PPIs must be taken 15-30 minutes before the morning meal.
- B. mechanism of PPI action consists in an irreversible inhibition of H+/K+-ATPase of the gastric parietal cells.
- C. chronic use of PPIs in patients with Helicobacter pylori infection may lead to atrophic gastritis.
- D. PPIs increase moderately serum gastrin concentrations.
- E. in patients with Zollinger-Ellison syndrome PPIs are recommended at a dose several fold higher than the standard one.
Hint
Look for the absolute wording and ask whether every PPI formulation really depends on meal timing.
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