Question 2 · LEK · Hypertrophic cardiomyopathy

Which of the following medications should be avoided in the patient with hypertrophic cardiomyopathy, with left ventricular outflow tract peak instantaneous pressure gradient 35 mmHg (measured with Doppler echocardiography), left ventricular ejection fraction 52%, symptoms of heart failure NYHA class II and chest pain:

1) nonsteroidal anti-inflammatory drugs;
2) non-vasodilating beta-blockers;
3) non-dihydropyridine calcium channel blockers;
4) long-acting oral nitrates;
5) digoxin.
The correct answer is:
  1. A. 1,3,4.
  2. B. 1,4,5.
  3. C. 2,3,5.
  4. D. 4,5.
  5. E. only 5.
Hint

Think about which drugs increase a dynamic outflow gradient by lowering preload/afterload or by increasing contractility.

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