Question 54 (part 2) · LEK · Characteristics of scientific studies

Studies on the role of vitamin D in the development of depression have shown that there is no relationship between these two variables. Previous cross-sectional studies showed that vitamin D deficiency was associated with depression when both of these phenomena were studied simultaneously. Which of Hill's criteria for causation were verified in subsequent prospective studies?

  1. A. reversibility.
  2. B. time dependence.
  3. C. biological credibility.
  4. D. analogy.
  5. E. dose-response relationship.
Hint

Cross-sectional studies cannot show which came first; consider what prospective follow-up adds.

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