Question 58 (part 2) · LEK · EBM

Rank the following sources of information on the effectiveness of drugs used in clinical practice from the most to the least scientifically credible:

1) Summary of Product Characteristics (medicines registered in Poland).
2) positions of Scientific Societies (e.g. the Polish Society of Cardiology).
3) meta-analysis of clinical trials (scientific publications in peer-reviewed magazines or of Cochrane Library type).
4) opinions of expert practitioners (e.g. such as those presented on the uptodate.com portal).
The correct answer is:
  1. A. 1,2,3,4.
  2. B. 3,2,4,1.
  3. C. 1,4,2,3.
  4. D. 2,3,4,1.
  5. E. 4,3,2,1.
Hint

Apply the evidence-based medicine hierarchy: syntheses of trials sit at the top, documents not designed to grade evidence come last.

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