Question 360 · LEK · Cross-cutting topics
Indicate false statement(s) regarding coagulopathies:
1) haemophilia type A is inherited in an autosomal recessive manner;
2) haemophilia type A results from a deficiency of factor VIII;
3) haemophilia type B is inherited in an autosomal dominant manner;
4) in 80% of cases there is a positive family history, while sporadic cases are caused by new mutations;
5) haemophilia types A and B occur mainly in boys; females are carriers, although the disease may also occur in girls;
6) typical manifestations of haemophilia include intra-articular and intra-muscular bleeding;
7) the severe form of haemophilia type B is diagnosed when factor VIII activity is below 1%.
The correct answer is:
2) haemophilia type A results from a deficiency of factor VIII;
3) haemophilia type B is inherited in an autosomal dominant manner;
4) in 80% of cases there is a positive family history, while sporadic cases are caused by new mutations;
5) haemophilia types A and B occur mainly in boys; females are carriers, although the disease may also occur in girls;
6) typical manifestations of haemophilia include intra-articular and intra-muscular bleeding;
7) the severe form of haemophilia type B is diagnosed when factor VIII activity is below 1%.
The correct answer is:
- A. only 7.
- B. 1,3.
- C. 1,3,7.
- D. 1,2,3,4,5,6.
- E. all of the above.
Hint
Check each statement for the inheritance pattern and for which clotting factor is deficient in each type of haemophilia.
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