KROK 1 2007 – Question 145 · KROK (Medicine) · Pharmacology
A patient who has been suffering from cardiac insufficiency for several months has been taking digoxin on an outpatient basis. At a certain stage of treatment there appeared symptoms of drug overdose. What phenomenon underlies the development of this complication?
- A. Habituation
- B. Functional cumulation
- C. Material cumulation
- D. Tachyphylaxis
- E. Sensibilization
Hint
Think about a glycoside with a long half-life that is eliminated slowly, so that each daily dose adds to what is already present in the body.
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