KROK 1 2008 – Question 183 · KROK (Medicine) · Pharmacology
A patient with bacterial pneumonia was prescribed benzylpenicillin. What is the mechanism of its antibacterial effect?
- A. Abnormal permeability of cytoplasmic membrane
- B. Antagonism with p-amino-benzoic acid
- C. Inhibition of SH-groups of microorganism enzymes
- D. Inhibition of intracellular protein synthesis
- E. Inhibition of synthesis of microorganism wall
Hint
Penicillins are β-lactams that bind penicillin-binding proteins; decide which bacterial-specific target those proteins belong to, and compare it with the targets of sulfonamides, aminoglycosides and polymyxins.
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