KROK 1 2008 – Question 134 · KROK (Medicine) · Pharmacology
A patient ill with chronic cardiac insufficiency was prescribed an average therapeutic dose of digoxin. Two weeks after begin of its taking there appeared symptoms of drug intoxication (bradycardia, extrasystole, nausea). Name the phenomenon that caused accumulation of the drug in the organism?
- A. Functional cumulation
- B. Idiosyncrasy
- C. Material cumulation
- D. Tachyphylaxis
- E. Tolerance
Hint
Consider how the slow elimination of digoxin affects the amount of drug in the body during regular dosing, and which of the listed terms names that kind of build-up rather than a change in the response to the drug.
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