KROK 1 2008 – Question 80 · KROK (Medicine) · Biological Chemistry

Vitamin B1 deficiency results in disturbance of oxidative decarboxylation of α-ketoglutaric acid. This will disturb synthesis of the following coenzyme:

  1. A. Lipoic acid
  2. B. Coenzyme A
  3. C. Flavine adenine dinucleotide (FAD)
  4. D. Thiamine pyrophosphate
  5. E. Nicotinamide adenine dinucleotide (NAD)
Hint

Ask which active coenzyme form is made directly from the deficient vitamin by phosphorylation, and is needed by the first enzyme of the α-ketoglutarate dehydrogenase complex.

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