KROK 1 2023 – Question 40 · KROK (Medicine) · Biological Chemistry
A patient diagnosed with diabetes mellitus presents with increased levels of ketone bodies in the blood. From what compound are ketone bodies synthesized?
- A. Acyl-CoA
- B. Succinyl-CoA
- C. Acetyl-CoA
- D. Butyryl-CoA
- E. Oxyacyl-CoA
Hint
In diabetes fatty acid oxidation is high but the citric acid cycle is short of oxaloacetate; think about which product of β-oxidation therefore piles up in liver mitochondria and is diverted into ketone body synthesis.
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