KROK 1 2020 – Question 129 · KROK (Medicine) · Pathophysiology

A 20-year-old man from the early childhood suffered from type I diabetes mellitus and was constantly undergoing insulin therapy. Within the last year he started breaking his diet and was taking his insulin doses irregularly. To detect possible complications, particularly glomerular diseases, the endocrinologist referred him for urinalysis. What is the first persistent sign of glomerular filtration disorder?

  1. A. Oxaluria
  2. B. Leukocyturia
  3. C. Hematuria
  4. D. Cylindruria
  5. E. Proteinuria
Hint

Think of what the intact glomerular barrier normally holds back in the blood according to size and charge, and which urinary finding appears first when that barrier begins to leak.

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