KROK 1 2019 – Question 174 · KROK (Medicine) · Microbiology, Virology, and Immunology

A 43-year-old man seeks evaluation at an emergency department with complaints of fever with chills, malaise, diffuse abdominal pain for over a week, diarrhea and loss of appetite. He says that his symptoms are progressively getting worse. He recalls that the fever began slowly and climbed its way up stepwise to the current 39.8°C. His blood pressure is 110/70 mm Hg. A physical exam reveals a coated tongue, enlarged spleen and rose spots on the abdomen. Serologic study shows the agglutinin O titre of 1:200 by the Widal test. Which of the following is the most likely causative organism for this patient’s condition?

  1. A. Salmonella typhi
  2. B. Leptospira interrogans
  3. C. Mycobacterium tuberculosis
  4. D. Enterohemorrhagic E. coli
  5. E. Vibrio cholerae
Hint

Consider what the Widal reaction detects and how stepwise fever, an enlarged spleen and skin spots point to a systemic bacteremic illness rather than a purely intestinal one.

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