KROK 1 2019 – Question 151 · KROK (Medicine) · Pathomorphology

A 40-year-old woman dies of intracerebral hemorrhage after the hypertensive emergency. During an autopsy, the pathologist reveals severe obesity, excess of body hair and wide purplish stria on the abdomen. Microscopic examination of pituitary gland reveals hyperplastic acini populated by a homogenous cluster of deeply basophilic cells. Which of the following was the most likely underlying disease?

  1. A. Cushing disease
  2. B. Sheehan’s syndrome
  3. C. Hyperthyroidism
  4. D. Arterial hypertension
  5. E. -
Hint

Link the body habitus and the abdominal striae to the pituitary cell type, and ask which hormone excess would produce this whole picture.

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