KROK 1 2015 – Question 111 · KROK (Medicine) · Pharmacology
When treating a patient with chronic cardiac failure a doctor detected bradycardia and deterioration of the patient’s general state. Such condition is caused by cumulative effect of a drug. Which drug of those listed below has cumulative action?
- A. Hydrochlorothiazide
- B. Retinol acetate
- C. Diphenhydramine (Dimedrol)
- D. Isosorbide
- E. Digoxin
Hint
Ask which drug in a heart-failure regimen is eliminated so slowly, and has such a narrow safety margin, that repeated doses build up and produce toxic effects on the heart.
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