KROK 1 2014 – Question 103 · KROK (Medicine) · Pharmacology
A patient who had been taking diclofenac sodium for arthritis of mandibular joint developed an acute condition of gastric ulcer. Such side effect of this medicine is caused by inhibition of the following enzyme:
- A. Phosphodiesterase
- B. Cyclooxygenase-2 (COX-2)
- C. Lipoxygenase
- D. Cyclooxygenase-1 (COX-1)
- E. Monoamine oxidase
Hint
Ask what normally protects the gastric mucosa and how an anti-inflammatory drug that blocks prostaglandin synthesis could remove that protection.
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