KROK 1 2011 – Question 100 · KROK (Medicine) · Pathophysiology
A 19-year-old female patient has had low haemoglobin rate of 90-95 g/l since childhood. Blood count results obtained after hospitalisation are as follows: erythrocytes - 3,2 · 10¹²/l, Hb- 85 g/l, colour index - 0,78; leukocytes - 5,6 · 10⁹/l, platelets - 210 · 10⁹/l. Smear examination revealed anisocytosis, poikilocytosis and target cells. Reticulocyte rate is 6%. Iron therapy was ineffective. What blood pathology corresponds with the described clinical presentations?
- A. Thalassemia
- B. Sickle-cell anemia
- C. Enzymopathy
- D. Favism
- E. Membranopathy
Hint
Consider why a chronic, early-onset hypochromic anaemia with target cells and reticulocytosis does not respond to iron, and what kind of production defect that suggests.
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