Question 114 (part 2) · LEK · Ovarian cancer
Which of the following is true about ovarian cancer in patients who carry BRCA1 and/or BRCA2 gene mutations:
1) on average, it occurs 10 years earlier than ovarian cancer that is not related to the mutations;
2) on average, it occurs 10 years later than ovarian cancer that is not related to the mutations;
3) it is more sensitive to systemic treatment than ovarian cancer that is not related to the mutations;
4) it is less sensitive to systemic treatment than ovarian cancer that is not related to the mutations;
5) in most cases it is a cancer of high histological malignancy G3.
The correct answer is:
2) on average, it occurs 10 years later than ovarian cancer that is not related to the mutations;
3) it is more sensitive to systemic treatment than ovarian cancer that is not related to the mutations;
4) it is less sensitive to systemic treatment than ovarian cancer that is not related to the mutations;
5) in most cases it is a cancer of high histological malignancy G3.
The correct answer is:
- A. 1,2,3.
- B. 2,3,4.
- C. 1,2,5.
- D. 1,3,5.
- E. 1,2,3,4.
Hint
Consider age at onset, typical histology and the effect of defective homologous recombination repair on response to platinum.
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