Question 52 (part 2) · LEK · Hyperthyroidism
Amiodarone-induced hyperthyroidism type 2 is characterised by:
- A. an iodine-induced, increased synthesis of thyroid hormones in patients with a concomitant thyroid disease such as latent Graves’ disease (an example of the Jod-Basedow effect).
- B. thyroiditis, which is a direct effect of the cytotoxic properties of amiodarone.
- C. increased iodine uptake.
- D. poor response to treatment with glucocorticoids.
- E. prompt resolution after amiodarone is discontinued.
Hint
Distinguish the iodine-load mechanism (type 1) from the direct drug-toxicity mechanism (type 2) and what each means for treatment.
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