Question 395 · LEK · Kidney cysts
Indicate true statements regarding autosomal dominant polycystic kidney disease (ADPKD):
1) it is most frequently due to polycystin gene mutation;
2) the course of the disease is progressive, leading to end-stage renal failure;
3) ACEI/ARB are the treatment of choice for comorbid hypertension;
4) the use of vasopressin V2 receptor antagonist slows down the cyst growth;
5) the most frequent non-renal manifestation are hepatic cysts.
The correct answer is:
2) the course of the disease is progressive, leading to end-stage renal failure;
3) ACEI/ARB are the treatment of choice for comorbid hypertension;
4) the use of vasopressin V2 receptor antagonist slows down the cyst growth;
5) the most frequent non-renal manifestation are hepatic cysts.
The correct answer is:
- A. 1,2,3.
- B. 2,3,4.
- C. 2,4,5.
- D. 2,3,4,5.
- E. all of the above.
Hint
Recall the PKD1/PKD2 genes, the natural history, the role of RAAS blockade, tolvaptan and the most common extrarenal cysts.
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