Question 144 · LEK · Treatment of hypertension with comorbidities

Which of the following is preferred in the treatment of severe (grade III) arterial hypertension in chronic kidney disease in patients with marked proteinuria and peripheral edemas, hyperkaliemia of 6.6 mmol/L and GFR < 30 ml/min/1.73 m2?

  1. A. angiotensin-converting-enzyme inhibitor (ACEI) with a loop diuretic.
  2. B. angiotensin II receptor blocker (ARB) with a thiazide diuretic.
  3. C. angiotensin-converting-enzyme inhibitor (ACEI) with angiotensin II receptor blocker (ARB).
  4. D. loop diuretic with a calcium channel antagonist.
  5. E. angiotensin II receptor blocker (ARB) in monotherapy.
Hint

Severe hyperkalemia and advanced CKD rule out drugs that raise potassium; which agents lower potassium and fluid?

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