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Question 93 · LEK · Hepatitis C

A 68-year-old patient came to the Infectious Diseases Outpatient Clinic with a diagnosis of chronic hepatitis C, and F3 fibrosis confirmed in elastographic examination. He also suffers from ischemic heart disease. Indicate the adequate statement on the recommended treatment and prognosis:

  1. A. treatment of chronic HCV infections is limited to pegylated interferon which allows full recovery in 90% of patients, but such treatment is contraindicated in the patient because of their ischemic heart disease.
  2. B. the patient will not be treated because in Poland antiviral treatment of chronic hepatitis C is not covered by the National Health Fund for patients older than 65.
  3. C. treatment with pegylated interferon α associated with ribavirin and telaprevir for 11 months, which leads to sustained virologic response (SVR) in 80% of all treated, is optimal treatment currently recommended for the majority of patients, regardless of any comorbidities.
  4. D. patient does not need any antiviral treatment because of an early stage of liver fibrosis.
  5. E. oral therapy with two or three medications directly inhibiting HCV replication, which is aimed at curing HCV infection (genotype 1) in over 90% of cases.
Hint

Consider the current standard of care for chronic hepatitis C and whether older age, coronary disease or F3 fibrosis should limit treatment.

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