Question 10 · LEK · Lung diffusing capacity test

In which clinical circumstances a decrease in the diffusing capacity of the lung for carbon monoxide (DLCO) is observed?

1) interstitial pulmonary fibrosis;
2) alveolar hemorrhage;
3) well-controlled asthma;
4) pulmonary emphysema;
5) severe perfusion disturbances (e.g. pulmonary embolism).
The correct answer is:
  1. A. 1,2,5.
  2. B. 1,3.
  3. C. 1,4,5.
  4. D. 2,3,5.
  5. E. 1,2,3,4.
Hint

DLCO falls when the alveolar-capillary surface or pulmonary perfusion is reduced; consider what extra haemoglobin in the alveoli does to CO uptake.

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