Question 174 · LEK · Antipsychotics

A 23-year-old female was diagnosed with schizophrenia after a single seven-month psychotic episode (with hallucinations and delusions in the clinical picture). Ever since then she has been treated with a small dose of olanzapine, which caused all her psychotic symptoms to resolve. She has not reported any symptoms for 24 months now. How should her therapy be modified?

  1. A. the dose of olanzapine should be reduced and then, if the patient still does not report any symptoms, olanzapine should be discontinued.
  2. B. the dose of olanzapine should be reduced, but the drug should not be discontinued.
  3. C. the dose of olanzapine should be maintained at the current level, but the appointments with the psychiatrist can become rarer.
  4. D. the diagnosis should be revised as the patient possibly does not suffer from schizophrenia.
  5. E. olanzapine should be substituted with a long-acting depot antipsychotic drug such as haloperidol decanoate.
Hint

Consider the recommended length of maintenance therapy after a single first psychotic episode with full, sustained remission.

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