Question 173 · LEK · Antipsychotics

A 55-year-old female patient diagnosed with schizophrenia has been taking haloperidol for 25 years. The patient complains of constant symptoms of chewing, facial grimacing and lip-smacking. The symptoms persist although the dose of haloperidol has been reduced. Discontinuation of the neuroleptic results in persecutory delusions and imperative auditory hallucinations that command her to kill the members of her family. Which of the following antipsychotic drugs should haloperidol be substituted with in this patient?

  1. A. chlorprothixene.
  2. B. perazine.
  3. C. thioridazine.
  4. D. olanzapine.
  5. E. perphenazine.
Hint

Name the movement disorder caused by decades of a typical neuroleptic, then pick a drug with lower risk of it that still controls psychosis.

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