Question 15 · LEK · Mood stabilizers

In women taking oral contraceptives an interaction with normotymic medications may occur. Which of the following may be recommended as safe medications that do not lower plasma concentration of hormonal contraceptives?

1) lithium;
2) valproate;
3) carbamazepine;
4) second-generation antipsychotics;
5) lamotrigine.
The correct answer is:
  1. A. 1,3,4.
  2. B. 2,4,5.
  3. C. 1,2,4,5.
  4. D. 1,3,4,5.
  5. E. 2,3,4,5.
Hint

Identify the drug that is a potent inducer of the hepatic CYP3A4 enzymes that metabolise oestrogens and progestins.

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