Question 17 · LDEK · Local anesthetics
In the inflammatory infiltrated tissue, the local anesthetic:
- A. undergoes dissociation to the cation form.
- B. has elongated latency time.
- C. quickly reaches the sodium channel, but leaves it slowly.
- D. it blocks only the potassium channel.
- E. it starts working faster, but works shorter than in healthy tissues.
Hint
Think about how the lower tissue pH of inflammation shifts the base-cation equilibrium of an anaesthetic with a given pKa.
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