Question 21 · LDEK · Local anesthetics
Indicate the true statements concerning lidocaine:
1) it is metabolized in the liver by amidases and peptidases;
2) toxicity of lidocaine increases with a simultaneous use of benzodiazepines;
3) lidocaine is an antiarrhythmic drug, thanks to blocking the second phase of repolarization in the cells of the cardiac conduction system;
4) pKa of lidocaine is 7.8;
5) it is available in the form of hydrochlorides of pH ranging from 5.0 to 5.5.
The correct answer is:
2) toxicity of lidocaine increases with a simultaneous use of benzodiazepines;
3) lidocaine is an antiarrhythmic drug, thanks to blocking the second phase of repolarization in the cells of the cardiac conduction system;
4) pKa of lidocaine is 7.8;
5) it is available in the form of hydrochlorides of pH ranging from 5.0 to 5.5.
The correct answer is:
- A. 1,4,5.
- B. 2,3,4.
- C. 2,3,5.
- D. 4,5.
- E. 1,4.
Hint
Remember that lidocaine is an amide with a pKa near 7.8, sold as acidic solutions, and that benzodiazepines are used to treat its CNS toxicity.
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