KROK 1 2007 – Question 15 · KROK (Medicine) · Biology
In some regions of South Africa there is a spread sickle-shaped cell anemia, in which erythrocytes have shape of a sickle as a result of substitution of glutamic acid by valine in the hemoglobin molecule. What is the cause of this disease?
- A. Transduction
- B. Crossingover
- C. Genomic mutations
- D. Gene mutation
- E. Disturbance of mechanisms of genetic information realization
Hint
One amino acid replaced in the β-globin chain reflects a change in a single codon; decide at what level of hereditary material this lesion lies.
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