KROK 1 2016 – Question 141 · KROK (Medicine) · Biology

A 2-year-old boy is diagnosed with Down syndrome. What chromosomal changes can cause this disease?

  1. A. Trisomy 18
  2. B. Monosomy X
  3. C. Trisomy X
  4. D. Trisomy 13
  5. E. Trisomy 21
Hint

Recall which numerical chromosomal abnormality underlies this most frequent genetic cause of intellectual disability in children, and how the extra chromosome arises in meiosis.

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