KROK 1 2013 – Question 197 · KROK (Medicine) · Biology

Analysis of the family history of children with Van der Woude syndrome revealed that in their families one of the parents had the typical for this syndrome defects (cleft lip and palate, lip pits regardless of gender). What is the type of inheritance of this syndrome?

  1. A. Multifactorial
  2. B. Autosomal recessive
  3. C. X-linked dominant
  4. D. Autosomal dominant
  5. E. X-linked recessive
Hint

Work out the mode of inheritance from the pedigree clues: whether an affected parent is needed, whether the sexes differ, and how many mutant copies of the gene cause disease.

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