Question 103 (part 2) · LEK · Cervical cancer
Which of the following are true about oncogenic types of HPV:
1) they might cause cervical cancer;
2) they might cause malignant tumours of the oral cavity and nasopharynx;
3) integration of HPV DNA with a host cell causes the inhibition of the expression of two viral E6 and E7 proteins with a secondary expression of E1 and E2 proteins, which is considered to be the beginning of carcinogenesis;
4) cervical cancer almost always develops after an oncogenic HPV infection in untreated females;
5) TP53 suppression in a host cell promotes unlimited proliferation of the infected cell.
The correct answer is:
2) they might cause malignant tumours of the oral cavity and nasopharynx;
3) integration of HPV DNA with a host cell causes the inhibition of the expression of two viral E6 and E7 proteins with a secondary expression of E1 and E2 proteins, which is considered to be the beginning of carcinogenesis;
4) cervical cancer almost always develops after an oncogenic HPV infection in untreated females;
5) TP53 suppression in a host cell promotes unlimited proliferation of the infected cell.
The correct answer is:
- A. 1,3,4,5.
- B. 1,2,5.
- C. 2,3,5.
- D. 1,2,4.
- E. 1,2.
Hint
Recall which viral oncoproteins are overexpressed after integration of HPV DNA and what they do to p53 and Rb.
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